DSBs are more likely to occur in some genomic regions than others. Elucidating mechanisms shaping the DSB “landscape” requires identifying the biochemical factors involved, understanding how they ...

Meiosis is a specialised form of cell division that produces haploid gametes from diploid progenitor cells, ensuring the maintenance of chromosome number across generations. Central to this process is ...

Meiotic recombination assures genetic variation during breeding. During meiotic prophase I, chromosomes are organized in a loop-base array by a proteinaceous structure called meiotic chromosome axis ...

A research collaboration based in Kumamoto University (Japan) has clarified how homologous chromosome pairing--a process necessary for sperm and egg formation where paternally- and maternally-derived ...

Genetic information is exchanged between maternal and paternal chromosomes through meiotic recombination. Sperm and eggs receive chromosomes with mixed genetic information, providing genetic diversity ...

During meiosis, paternal and maternal chromosomes duplicate, pair, and exchange parts of their DNA in a process called meiotic recombination. In order to mediate this exchange of genetic material, ...

Recombination between homologous chromosomes is essential for successful meiosis. It drives genetic diversity in germline cells and provides the necessary scaffolding for accurate, balanced ...

One observation, made more than 80 years ago about precisely where on chromosomes crossovers happen, has fueled research in Dr. Gerry Smith’s laboratory in the Basic Sciences Division. That ...