Scientists from Oregon Health & Science University (OHSU) and the University of Edinburgh have discovered that a little-understood junction that connects neurons to oligodendrocyte precursor cells ...

When you interact with the world around you, your experiences are recorded as changes in the connection strengths between neurons in your brain. This process, called synaptic plasticity, alters how ...

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

By tagging neurons with molecular "barcodes," researchers have mapped connections among thousands of neurons in the mouse brain with unprecedented speed and resolution. The approach could expand ...

Establishment of neural circuits is a tightly regulated process coordinated by a series of cellular and molecular mechanisms. Within the neural circuitry electrical and chemical information is ...

The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of ...

A research team led by Dr. Àlex Bayés, Head of the Molecular Physiology of the Synapse Group at the Institut de Recerca Sant Pau (IR Sant Pau), has achieved what for decades had been an elusive goal: ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...

Scientists at HHMI's Janelia Research Campus have discovered a new kind of synapse in the tiny hairs on the surface of neurons. The commonly overlooked protrusions called primary cilia contain special ...

Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing ...